TITLE: NEDD9 Monoclonal Antibody Therapeutic for Pulmonary Thromboembolic Disease TYPE OF AWARD: Drive CLINICAL AREA:  Biologic INSTITUTION: Brigham and Women’s Hospital DESCRIPTION: Increased platelet-endothelial adhesion is a central pathobiological event underlying the pathogenesis of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). Current therapies to treat thrombosis in PAH and CTEPH emphasize non-specific coagulation proteins, and are associated…

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TITLE: Novel Small Molecule Therapeutics for Genetic Lung and Blood Diseases TYPE OF AWARD: Drive CLINICAL AREA:  Small Molecule INSTITUTION: Boston Children’s Hospital DESCRIPTION: Telomere diseases encompass a spectrum of rare and fatal syndromes that are caused by mutations in genes regulating telomere biology. These include the severe childhood blood disorder dyskeratosis congenita (DC) and later-onset diseases such as…

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Contributed by Ilsa Webeck B-BIC Skills Development Expert Developing Innovative Strategies for Leading Edge Medical Technology Companies “I have an idea. A great idea. I mean, it’s an “I can’t believe no one has thought of this before” idea. The market for this product is going to be enormous.”  In conversations with innovators spanning devices, biologics,…

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