TITLE: Technology for Functional and Metabolic Imaging with Hyperpolarized MRI TYPE OF AWARD: Pilot CLINICAL AREA:  Heart INSTITUTION:  Beth Israel Deaconess Medical Center DESCRIPTION: MRI provides a wealth of anatomical information, but its ability to assess functional parameters such as blood flow (perfusion) and metabolism is limited by its low sensitivity and the limited range of available contrast…

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Contributed by Erin McKenna, Deputy Director of B-BIC & Paul Tessier, B-BIC Coach Once you understand the unmet clinical need your technology can address and have connected that need with a solid business opportunity, the next thing to be considered is to understand the development path for the product you want to create. Outlining the…

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TITLE: NEDD9 Monoclonal Antibody Therapeutic for Pulmonary Thromboembolic Disease TYPE OF AWARD: Drive CLINICAL AREA:  Biologic INSTITUTION: Brigham and Women’s Hospital DESCRIPTION: Increased platelet-endothelial adhesion is a central pathobiological event underlying the pathogenesis of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). Current therapies to treat thrombosis in PAH and CTEPH emphasize non-specific coagulation proteins, and are associated…

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TITLE: Novel Small Molecule Therapeutics for Genetic Lung and Blood Diseases TYPE OF AWARD: Drive CLINICAL AREA:  Small Molecule INSTITUTION: Boston Children’s Hospital DESCRIPTION: Telomere diseases encompass a spectrum of rare and fatal syndromes that are caused by mutations in genes regulating telomere biology. These include the severe childhood blood disorder dyskeratosis congenita (DC) and later-onset diseases such as…

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Contributed by Ilsa Webeck B-BIC Skills Development Expert Developing Innovative Strategies for Leading Edge Medical Technology Companies “I have an idea. A great idea. I mean, it’s an “I can’t believe no one has thought of this before” idea. The market for this product is going to be enormous.”  In conversations with innovators spanning devices, biologics,…

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Written by Paul Tessier A common refrain heard by healthcare entrepreneurs is that they should focus on satisfying an “unmet clinical need,” however there is no universal definition of the phrase, “unmet clinical need.”  Even established companies and public healthcare agencies, who use the concept of an unmet clinical need to assist in developing product…

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We are thrilled to share with you a new web video we are releasing that highlights our ‘Commercialization Coaches’ and other services that are ways B-BIC successfully differentiates from other grants. Kantum Pharma, dedicated to the prevention and treatment of Acute Kidney Injury, received its first B-BIC Pilot grant in 2017.

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Technology in Search of an Application Part II of the Specialist Series: The Road to Commercialization: Challenges and Opportunities Written by John Randle Development models always start with addressing clinical needs, but scientific discoveries and technological advances typically happen independently from solving clinical problems. This article will explore ways you can ensure that you are…

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TITLE: Humanized anti-DEspR antibody therapy for acute respiratory distress syndrome TYPE OF AWARD: Drive CLINICAL AREA:  Lung INSTITUTION: Boston University DESCRIPTION: Acute respiratory distress syndrome (ARDS) and its progression to multi-organ failure (MOF) affects ~200,000 ICU patients each year in the US, with high mortality and healthcare costs. ARDS is driven by hyperinflammation-injury cycles that begin as a normal injury…

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TITLE: Generation of a Novel Therapeutic Antibody for Treatment of Allergic Asthma TYPE OF AWARD: Pilot CLINICAL AREA:  Lung INSTITUTION: Brigham and Women’s Hospital   DESCRIPTION: Asthma affects 8% of the US population, approximately 25 million people. About 10% of patients have severe asthma, accounting for an estimated 1.8 million emergency department visits, 439,000 hospitalizations, and 3,630 deaths annually…

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