TITLE: Technology for Functional and Metabolic Imaging with Hyperpolarized MRI TYPE OF AWARD: Pilot CLINICAL AREA:  Heart INSTITUTION:  Beth Israel Deaconess Medical Center DESCRIPTION: MRI provides a wealth of anatomical information, but its ability to assess functional parameters such as blood flow (perfusion) and metabolism is limited by its low sensitivity and the limited range of available contrast…

Read More

TITLE: NEDD9 Monoclonal Antibody Therapeutic for Pulmonary Thromboembolic Disease TYPE OF AWARD: Drive CLINICAL AREA:  Biologic INSTITUTION: Brigham and Women’s Hospital DESCRIPTION: Increased platelet-endothelial adhesion is a central pathobiological event underlying the pathogenesis of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). Current therapies to treat thrombosis in PAH and CTEPH emphasize non-specific coagulation proteins, and are associated…

Read More

TITLE: Novel Small Molecule Therapeutics for Genetic Lung and Blood Diseases TYPE OF AWARD: Drive CLINICAL AREA:  Small Molecule INSTITUTION: Boston Children’s Hospital DESCRIPTION: Telomere diseases encompass a spectrum of rare and fatal syndromes that are caused by mutations in genes regulating telomere biology. These include the severe childhood blood disorder dyskeratosis congenita (DC) and later-onset diseases such as…

Read More

TITLE: Generation of a Novel Therapeutic Antibody for Treatment of Allergic Asthma TYPE OF AWARD: Pilot CLINICAL AREA:  Lung INSTITUTION: Brigham and Women’s Hospital   DESCRIPTION: Asthma affects 8% of the US population, approximately 25 million people. About 10% of patients have severe asthma, accounting for an estimated 1.8 million emergency department visits, 439,000 hospitalizations, and 3,630 deaths annually…

Read More

TITLE: Diagnostic for Acute Kidney Injury Associated with Cardiovascular Diseases TYPE OF AWARD: Drive TECHNOLOGY TYPE:  Diagnostic INSTITUTION: MGH   DESCRIPTION:  Acute kidney injury (AKI) is a frequent complication in hospitalized patients, including those undergoing cardiac surgery. However, two critical barriers to the clinical management of these critically ill patients remain the need for better methods…

Read More

TITLE: A Rapid, Inexpensive Platelet Function Test TYPE OF AWARD: Pilot CLINICAL AREA:  Blood INSTITUTION: BIDMC DESCRIPTION:  Antiplatelet agents such as clopidogrel and aspirin are used in the treatment of heart attacks and strokes and are among the most commonly used drugs in the U.S. Problems associated with these drugs include bleeding risk (which complicates invasive…

Read More

TITLE: CardioptOx: A new real-time quantitative cardio-pulmonary monitoring technique for improved patient care. TYPE OF AWARD: Pilot TECHNOLOGY TYPE: Diagnostic Device CLINICAL AREA:  Heart INSTITUTION: Boston University DESCRIPTION: Approximately 600,000 deaths per year are attributed to cardiopulmonary disease in the US. Many patients suffering from cardiopulmonary disease experience complications that require hospital and intensive care unit (ICU) stays.…

Read More

RECIPIENT:  Dr. Jonghan Kim TITLE: Hydrogel-based nanochelator therapy for iron overload disorders TYPE OF AWARD: Drive TECHNOLOGY TYPE: Small Molecule CLINICAL AREA: Blood INSTITUTION: Northeastern & MGH DESCRIPTION: Iron overload, best represented by hereditary hemochromatosis (primary/genetic iron overload) and transfusional hemoglobinopathy (secondary/acquired iron overload), is a well-defined risk factor for several critical diseases, including heart failure, liver cirrhosis, arthritis,…

Read More

RECIPIENT:  Dr. J. Brian McAlvin TITLE: A Novel Method To Treat The Systemic Inflammatory Response Syndrome (SIRS) TYPE OF AWARD: Pilot TECHNOLOGY TYPE: Therapeutic Device CLINICAL AREA: Blood INSTITUTION: Boston Children’s Hospital DESCRIPTION: We have developed highly-selective blood-filtering devices that are capable of filtering of individual, harmful molecules from the blood of patients rendered critically ill by the…

Read More

RECIPIENT:  Dr. Sylvie Breton TITLE: Predicting and Preventing Acute Kidney Injury Associated with Cardiovascular Diseases TYPE OF AWARD:  PILOT TECHNOLOGY TYPE: Small Molecule Drug CLINICAL AREA: Heart INDICATION: Acute Kidney Injury INSTITUTION: MGH DESCRIPTION:  Acute kidney injury (AKI) is a frequent complication of hospitalized patients. Unfortunately, there is no cure for this potentially deadly condition. Thus, a critical…

Read More