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Unmet Clinical Need

By B-BIC | November 14, 2019

Written by Paul Tessier A common refrain heard by healthcare entrepreneurs is that they should focus on satisfying an “unmet clinical need,” however there is no universal definition of the phrase, “unmet clinical need.”  Even established companies and public healthcare agencies, who use the concept of an unmet clinical need to assist in developing product…

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B-BIC: ‘IS MORE THAN JUST FUNDING’, with Kantum Pharma

By B-BIC | October 14, 2019

We are thrilled to share with you a new web video we are releasing that highlights our ‘Commercialization Coaches’ and other services that are ways B-BIC successfully differentiates from other grants. Kantum Pharma, dedicated to the prevention and treatment of Acute Kidney Injury, received its first B-BIC Pilot grant in 2017.

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Specialist Series: Technology in Search of an Application

By B-BIC | October 9, 2019

Technology in Search of an Application Part II of the Specialist Series: The Road to Commercialization: Challenges and Opportunities Written by John Randle Development models always start with addressing clinical needs, but scientific discoveries and technological advances typically happen independently from solving clinical problems. This article will explore ways you can ensure that you are…

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NEW AWARD: Congratulations Dr. Nelson Ruiz-Opazo!!

By B-BIC | September 2, 2019

TITLE: Humanized anti-DEspR antibody therapy for acute respiratory distress syndrome TYPE OF AWARD: Drive CLINICAL AREA:  Lung INSTITUTION: Boston University DESCRIPTION: Acute respiratory distress syndrome (ARDS) and its progression to multi-organ failure (MOF) affects ~200,000 ICU patients each year in the US, with high mortality and healthcare costs. ARDS is driven by hyperinflammation-injury cycles that begin as a normal injury…

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NEW AWARD: Congratulations Dr. Steven Greenberg!!

By B-BIC | September 2, 2019

TITLE: Generation of a Novel Therapeutic Antibody for Treatment of Allergic Asthma TYPE OF AWARD: Pilot CLINICAL AREA:  Lung INSTITUTION: Brigham and Women’s Hospital   DESCRIPTION: Asthma affects 8% of the US population, approximately 25 million people. About 10% of patients have severe asthma, accounting for an estimated 1.8 million emergency department visits, 439,000 hospitalizations, and 3,630 deaths annually…

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The Road to Commercialization: Series Introduction

By B-BIC | September 2, 2019

Written by Erin McKenna, B-BIC Deputy Director There are multiple frameworks out there that outline the process for developing promising biomedical research into a range of innovative solutions – pharmaceuticals, biologics, medical devices, and diagnostics.  Many of these processes leverage concepts that come from regulations developed by the FDA, the European Commission and others to…

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The Breakdown of a B-BIC Proposal / Business Plan

By B-BIC | September 2, 2019

Over the course of 2019, our coaches and staff broke down the B-BIC application process to provide you with expert advice on all the of the questions we ask you to answer when applying for our program. For those who are not applying yet, the B-BIC proposal has many similarities to a business plan, which…

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Congratulations Dr. Sylvie Breton!

By B-BIC | May 27, 2019

TITLE: Diagnostic for Acute Kidney Injury Associated with Cardiovascular Diseases TYPE OF AWARD: Drive TECHNOLOGY TYPE:  Diagnostic INSTITUTION: MGH   DESCRIPTION:  Acute kidney injury (AKI) is a frequent complication in hospitalized patients, including those undergoing cardiac surgery. However, two critical barriers to the clinical management of these critically ill patients remain the need for better methods…

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New Award: Congratulations Dr. Robert Flaumenhaft!

By B-BIC | May 27, 2019

TITLE: A Rapid, Inexpensive Platelet Function Test TYPE OF AWARD: Pilot CLINICAL AREA:  Blood INSTITUTION: BIDMC DESCRIPTION:  Antiplatelet agents such as clopidogrel and aspirin are used in the treatment of heart attacks and strokes and are among the most commonly used drugs in the U.S. Problems associated with these drugs include bleeding risk (which complicates invasive…

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SPECIALIST SERIES: What Is An Investible Hypothesis?

By B-BIC | May 26, 2019

By Jay Knowles Partner, Innovation Many venture capitalists look for opportunities to invest in a company or a project such that if it reaches a certain inflection point, that company will become significantly more valuable, and what it will cost to get it to that point. As an example, investors often like to see how…

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